Tuesday, September 28, 2010

Evan Keller, University of Michigan

Three Problems:
  • Why is prostate cancer osteoblastic (i.e. most cancers when they spread to bone result in bone resorption (i.e., osteolytic); whereas, prostate cancer results in bone production (i.e. osteoblastic).
  • Why does prostate cancer preferentially metastasize to bone as opposed to other sites.
  • How can we successfully treat metastases that are highly heterogenous (i.e  within one patient, different metastases have different properties).
Background Papers:

Monday, September 27, 2010

Robert Getzenberg, Johns Hopkins University

Three Questions:
  • Metastatic cancer cells have amplified evolutionary capabilities that allow them to develop resistance to therapeutic approaches.  This may be enhanced by niches/microenvironments being emptied by “sensitive” populations that do not survive.  What role do physical and/or structural properties play in the development of resistance and how can modification of these by used to hinder the evolution of cancer?
  • The concept that cancer cells metastasize as single cells may not be correct.  Groups of cancers cells along with what appear to be perhaps supporting players have been identified.  Do cells, other than the tumor cells themselves, “travel” with the cancer cell and aid in the development of metastatic sites?  If so, are they from the site of origin or are they recruited from other sources?  Can we image these?
  • It appears that heat can be used to increase the sensitivity cancer cells to other forms of therapy and that the price that the cancer cells pays for being so able to develop resistance to therapy is a sensitivity to microenvironmental stresses.  What physical properties of the cells have been altered that creates this sensitivity to stresses?  

Don Coffey, Johns Hopkins University

Central Question:
Why is there so much variation (heterogeneity) within solid tumors in relation to  cell structure and function and how might this relate to energy, information transfer, and self-organization?

Thursday, September 23, 2010

Gary Stein, University of Massachusetts

Three Problems:
  • Epigenetic control in tumorigenesis, tumor progression and metastasis 1
  • Nuclear microenvironments in biological control and cancer 2
  • Cell adhesion and motility in tumor progression 3


Lance Munn, Harvard

Three Questions:
  • Can we identify patients who would benefit from treatment aimed at preventing metastasis or further metastasis? 
  • How does the accumulation of compressive stress affect invasion and metastasis?
  • What role do host stromal cells or cancer cell cooperation play in invasion and metastasis?

Background Papers:

Monday, September 20, 2010

Yibin Kang, Princeton

  • Do tumor cells behave differently as solitary cells (disseminated tumor cells or micrometastasis) and as overt metastasis.  Is a critical mass required for tumor cells to manifest their full malignant potential and how does this relates to metastatic dormancy?
  • Is there a fitness cost for tumor cells to overcome different hurdles of metastasis?  For example, when tumor cells undergo epithelial mesenchymal transition to invade and migrate, are they more susceptible to certain drugs. 
  • What are the key molecular pathways that mediate tumor-stromal interactions in metastasis?  How to we effectively deliver therapeutics to disseminated tumor cells or micrometastasis to prevent distant recurrence?
Background Papers

Friday, September 17, 2010

Ken Pienta, University of Michigan

Three questions:
  • How efficient is the metastatic process? What are the qualities of a cancer cell that is a successful metastatic seed?
  • How do the physical qualities of the target organ affect the establishment of a metastasis?
  • How do cells survive the turbulence of the circulation?

Background Papers:

Thursday, September 16, 2010

Meeting Logistics

November 1-2, 2010 (October 31st, registration and opening discussion with refreshments in the evening for those available, time 6-8pm.)

Hilton-Arlington, 950 North Stafford Street, Arlington, VA 22203
Note: Reservations and hotel payment will be made via meeting coordinator.  Please forward your reservation dates to Sara

Directions & Transportation: Link

Please make your own travel arrangements.  Attendee's are encouraged to make air/ground transportation reservations as early as possible to capitalize on reduced fares. Currently, the organizers are budgeted for air travel at the following RT rates: West coast ~$700; Mid-West, ~$600; and East Coast, ~$300. Air/ground transportation will be reimbursed after the meeting by UCSD. You will be given detailed instructions on how to submit your travel reimbursements at or shortly after the meeting.

Please be aware of the following restrictions: UC will reimburse you for economy/coach class air travel (or the equivalent of an economy/coach fare if you decide to fly business/first class) and original receipts are required. For those living within driving distance,  you may receive a mileage per diem (and parking fee reimbursement) if you use your personal vehicle. Taxis, shuttles and train expenses (within reasonable limits) will also be reimbursed.

Please forward your itinerary and ticket price to the meeting coordinator, Sara Bradley at sara.bradley@comcast.net.

Sunday, October 31st: registration and opening discussion with refreshments in the evening for those available, time 6-8pm.
Monday, November 1: talks and discussion will run the full day on Monday, dinner to follow.
Tuesday, November 2: talks and discussion will run to approximately 3pm.
Detailed agenda tba.

Meeting Coordinator:
Sara Bradley