- Do tumor cells behave differently as solitary cells (disseminated tumor cells or micrometastasis) and as overt metastasis. Is a critical mass required for tumor cells to manifest their full malignant potential and how does this relates to metastatic dormancy?
- Is there a fitness cost for tumor cells to overcome different hurdles of metastasis? For example, when tumor cells undergo epithelial mesenchymal transition to invade and migrate, are they more susceptible to certain drugs.
- What are the key molecular pathways that mediate tumor-stromal interactions in metastasis? How to we effectively deliver therapeutics to disseminated tumor cells or micrometastasis to prevent distant recurrence?
Monday, September 20, 2010
Yibin Kang, Princeton