Robert Getzenberg (JHU) & Don Coffey (JHU) : Additional Material

These three articles will flow towards the metastatic aspects of the concepts in our discussions. 

 

We understand that Dr. Michor is attending the meeting but wanted to include one of the papers on which she is an author since it raises what we feel is a very important concept.  This manuscript on quasispecies connects chromosome structure to evolution and cancer and introduces some mathematical issues.  The recent paper on pattern recognition will provide a link to the physics on this topic. We are sure that Herb Levine will apply his vast experience to this problem.  The last of the papers is an old review on the tissue matrix that sets the background for the structural aspects of what we will discuss. 

Background Papers:

• Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation
• Genetic instability and the quasispecies model
• The Tissue Matrix: Cell Dynamics and Hormone Action

Don Coffey, Johns Hopkins University

Central Question:

Why is there so much variation (heterogeneity) within solid tumors in relation to  cell structure and function and how might this relate to energy, information transfer, and self-organization?