Lance Munn, Harvard

Three Questions:

• Can we identify patients who would benefit from treatment aimed at preventing metastasis or further metastasis? 
• How does the accumulation of compressive stress affect invasion and metastasis?
• What role do host stromal cells or cancer cell cooperation play in invasion and metastasis?

 

Background Papers:

• Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis
• Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed?
• Mechanisms of collective cell migration at a glance