Tuesday, October 5, 2010

Scott Guelcher, Vanderbilt

Three Questions:
  • What characteristics unique to the bone microenvironment induce tumor cells to express osteolytic factors after the tumor becomes established in bone?
  • Over what range of tissue-level mechanical properties can tumor cells respond to the rigidity of the microenvironment?
  • Are tumor cells genetically programmed to metastasize to bone or are they attracted to the unique characteristics of the bone microenvironment?

Background Papers:

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