Wednesday, October 6, 2010

Chuck Drake, Johns Hopkins University

Three Problems:
  • Do cancer cells metastasize as single cells, as clusters of tumor cells, as clusters of tumor and myeloid cells, or as fusions between tumor cells and macrophages?
  • What is the relative role of passive (fluid dynamic) versus active processes (diapedesis, extravascation) in the establishment of metastases from tumor cells circulating in the vascular or lymphatic compartments?
  • At what stage in the metastatic process are tumor cells most susceptible to immunological intervention? 
Background Papers:

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