Ken Pienta, University of Michigan

Three questions:

• How efficient is the metastatic process? What are the qualities of a cancer cell that is a successful metastatic seed?
• How do the physical qualities of the target organ affect the establishment of a metastasis?
• How do cells survive the turbulence of the circulation?

Background Papers:

• The Lethal Phenotype of Cancer: The Molecular Basis of Death Due to Malignancy
• Pathogenesis and Treatment of Prostate Cancer Bone Metastases: Targeting the Lethal Phenotype